Product Overview
The refurbished Agilent 6490A Triple Quadrupole LC-MS/MS System (G6490A) is designed for sensitive, targeted quantitative analysis using multiple reaction monitoring (MRM). Its iFunnel ion-optics design combines Agilent Jet Stream technology, a hexabore sampling capillary and dual ion funnels to improve ion transfer into the mass analyzer.
The 6490A can be quoted as a mass-spectrometer platform for connection to a compatible laboratory LC or as part of a configured LC-MS/MS system. Available LC modules, source, workstation, MassHunter software, licenses, nitrogen supply, vacuum equipment and accessories depend on inventory and the Jant quotation.
Jant can also support laboratories with custom premixed LC-MS/MS internal standards and quality-control materials and LC-MS/MS method transfer and validation services.
iFunnel Ion Optics
Jet Stream ionization, a hexabore capillary and dual ion funnels support efficient ion generation and transfer.
20 ms Polarity Switching
Fast positive-to-negative polarity switching supports mixed-polarity compounds in one method.
500 MRM Transitions/s
Dynamic MRM and short dwell times support demanding multi-analyte quantitative methods.
Key Features
- Triple-quadrupole LC-MS/MS platform for targeted quantitative analysis
- iFunnel design incorporating Agilent Jet Stream ionization, a hexabore sampling capillary and dual ion funnels
- Mass range of m/z 5-1,400
- Maximum scan rate of 10,000 Da/s
- Polarity switching in 20 ms
- Minimum MRM dwell time of 1 ms
- Up to 500 MRM transitions per second
- Dynamic MRM for scheduling large numbers of transitions around expected retention times
- Triggered MRM for compound confirmation and library-search workflows
- High-pressure collision cell designed for rapid ion clearing
- Automated positive- and negative-mode tuning and mass-axis calibration
- Compatible ionization options may include Agilent Jet Stream electrospray and multimode ionization, depending on the quoted source configuration
Product Specifications
| Jant Catalog Number | ALT6490A |
|---|---|
| Model | Agilent 6490A Triple Quadrupole LC-MS/MS, G6490A |
| Condition | Refurbished |
| Analyzer Type | Triple quadrupole with iFunnel ion optics |
| Mass Range | m/z 5-1,400 |
| Maximum Scan Rate | 10,000 Da/s |
| Polarity Switching | 20 ms |
| Resolution | 0.4 amu FWHM |
| Mass Accuracy | 0.1 Da or 0.01%, whichever is greater |
| Mass Stability | Less than 0.1 u over 48 hours |
| Minimum MRM Dwell Time | 1 ms |
| MRM Acquisition | Up to 500 MRM transitions per second; dynamic MRM supports more than 40,000 transitions per method |
| Acquisition Modes | MS scan, SIM, MRM, dynamic MRM, triggered MRM, product-ion scan, precursor-ion scan and neutral-loss/gain scan |
| Unit of Measurement | Each |
Published specifications describe the model platform under specified test conditions. Actual refurbished-system performance depends on condition, configuration, source, tuning, software, LC configuration, method and maintenance status.
Targeted LC-MS/MS Applications
Clinical and Toxicology Research
- Targeted drug panels
- Drug-monitoring research
- Toxicology method development
- Multi-analyte quantitation
Pharma and Bioanalysis
- ADME research
- Pharmacokinetic studies
- Peptide quantitation
- Drug discovery workflows
Food and Environmental Research
- Pesticide analysis
- Contaminant monitoring
- Residue analysis
- Complex-matrix methods
Application suitability and regulatory status depend on the complete configuration, validated method and intended use.
Available System Configurations
Mass Spectrometer Platform
The 6490A may be quoted for connection to an existing compatible LC. Confirm interface requirements, source, workstation, software, vacuum equipment, gases and installation scope.
Configured LC-MS/MS System
A compatible Agilent 1260 or 1290 LC configuration may be available. Module models and included hardware vary by inventory and must be listed individually in the quotation.
Compare Refurbished Agilent LC-MS Systems
| System | Analyzer | Best Fit | Key Distinction |
|---|---|---|---|
| Agilent 6460C | Triple quadrupole | Routine targeted quantitation | m/z 5-3,000 and 30 ms polarity switching |
| Agilent 6490A | Triple quadrupole with iFunnel | Demanding targeted quantitation | iFunnel ion optics and 20 ms polarity switching |
| Agilent 6550A | Quadrupole time-of-flight | Accurate-mass identification and non-targeted research | High-resolution accurate-mass MS and MS/MS |
Analyzer selection should be based on method goals, required sensitivity and selectivity, acquisition strategy, existing methods, software, regulatory requirements and serviceability.
LC-MS/MS Workflow Support
Explore Jant resources for LC-MS/MS instrumentation, custom reagents and method support.
Browse LC-MS Products and Services Custom LC-MS/MS Reagents Method Transfer and Validation Request an ROI ProposalImportant Refurbished-System Information
- Confirm instrument serial number, refurbishment scope, test results and cosmetic condition.
- Confirm whether the quote is for the mass spectrometer only or a complete LC-MS/MS configuration.
- Confirm all LC modules, ion source, probes, vacuum pumps, nitrogen generator or gas requirements, workstation, monitor, software versions, licenses, cables and accessories.
- Installation and starter materials are listed separately on the current Jant page unless included in the quotation.
- The current Jant page states a 90-day warranty with a one-year upgrade option; confirm current coverage, exclusions and service availability in writing.
- Confirm whether IQ/OQ, preventive maintenance, training and method services are included or available separately.
- Regulatory status depends on the exact configuration, documentation and intended use. Do not assume that a refurbished research configuration is cleared for diagnostic use.
Documentation and Resources
Review the Agilent 6400 Series guides hosted by Jant and request documentation for the exact refurbished configuration being quoted.
Agilent 6400 Series Concepts Guide Agilent 6400 Series Quick Start GuideFrequently Asked Questions
The 6490A is a triple-quadrupole LC-MS/MS platform designed for targeted quantitative analysis using MRM-based acquisition. Application suitability depends on the method, configuration and intended use.
The 6490A iFunnel design combines Agilent Jet Stream ionization, a hexabore sampling capillary and dual ion funnels to improve ion generation and transfer into the mass analyzer.
Both are triple-quadrupole instruments for targeted quantitation. The 6490A adds iFunnel ion optics and 20 ms polarity switching, while the 6460C has a broader published mass range of m/z 5-3,000. The right choice depends on the method and required performance.
The 6550A is a high-resolution accurate-mass Q-TOF system designed for compound identification, profiling and non-targeted or confirmation research. It is not simply another triple quadrupole; the analyzer and acquisition goals are different.
Not necessarily. The 6490A may be quoted as a mass-spectrometer platform or with a compatible LC configuration. Confirm every LC module and accessory in the quotation.
Software, license version, workstation and computer hardware are configuration-specific. They should be listed explicitly in the Jant quotation.
The current Jant listing states a 90-day warranty and indicates that a one-year upgrade may be available. Confirm the current warranty, covered components, response terms and exclusions before purchase.
Confirm the serial number, refurbishment and test documentation, LC configuration, source, probes, pumps, gas requirements, workstation, software and licenses, installation, training, warranty, serviceability, shipping and regulatory designation.
Ordering Information
To request availability, configuration details or a quote, call Jant Pharmacal at 800.676.5565
| Catalog Number | Description | Unit of Measurement |
|---|---|---|
| ALT6490A | Agilent 6490A Triple Quadrupole LC-MS/MS System – Refurbished | Each |
Please confirm the complete configuration, included LC modules and accessories, condition, software, warranty, installation and service coverage when requesting a quote.