Product Overview
The refurbished Agilent 6460C Triple Quadrupole LC-MS/MS System (G6460C) is designed for targeted quantitative analysis using multiple reaction monitoring (MRM). Agilent Jet Stream ionization, fast scanning and dynamic MRM support multi-analyte methods across pharmaceutical, bioanalytical, toxicology-research, food and environmental workflows.
The 6460C can be quoted as a mass-spectrometer platform for connection to a compatible laboratory LC or as part of a configured LC-MS/MS system. Available LC modules, source, workstation, MassHunter software, licenses, nitrogen supply, vacuum equipment and accessories depend on inventory and the Jant quotation.
Jant can also support laboratories with custom premixed LC-MS/MS internal standards and quality-control materials and LC-MS/MS method transfer and validation services.
Targeted Quantitation
Triple-quadrupole architecture supports MRM, dynamic MRM and triggered MRM acquisition.
12,500 Da/s Scan Rate
Fast scanning and minimum MRM dwell times of 1 ms support multi-compound methods.
Agilent Jet Stream
Jet Stream ion focusing is designed to improve ion generation and transfer for compatible electrospray workflows.
Key Features
- Triple-quadrupole LC-MS/MS platform for targeted quantitative analysis
- Agilent Jet Stream electrospray ionization capability
- Mass range of m/z 5-3,000
- Maximum scan rate of 12,500 Da/s
- Polarity switching in 30 ms
- Minimum MRM dwell time of 1 ms
- Up to 450 MRM transitions per time segment
- Dynamic MRM methods with up to 4,000 ion transitions
- Triggered MRM for compound confirmation and library-search workflows
- High-pressure collision cell with ion clearance of less than 1 ms
- Automated positive- and negative-mode tuning and mass-axis calibration
- Compatible ionization options may include ESI, APCI, multimode and APPI, depending on the quoted source configuration
Product Specifications
| Jant Catalog Number | ALT6460C |
|---|---|
| Model | Agilent 6460C Triple Quadrupole LC-MS/MS, G6460C |
| Condition | Refurbished |
| Analyzer Type | Triple quadrupole |
| Mass Range | m/z 5-3,000 |
| Maximum Scan Rate | 12,500 Da/s |
| Polarity Switching | 30 ms |
| Resolution | 0.7 Da FWHM with autotune; 0.5 Da FWHM with manual tuning |
| Mass Accuracy | 0.1 Da from m/z 5-1,000; 0.01% from m/z 1,000-2,000; 0.02% from m/z 2,000-3,000 |
| Mass Stability | Less than 0.1 Da over 24 hours |
| Minimum MRM Dwell Time | 1 ms |
| Acquisition Modes | MS scan, SIM, MRM, product-ion scan, precursor-ion scan and neutral-loss/gain scan |
| Unit of Measurement | Each |
Published specifications describe the model platform under specified test conditions. Actual refurbished-system performance depends on condition, configuration, source, tuning, software, LC configuration, method and maintenance status.
Targeted LC-MS/MS Applications
Clinical and Toxicology Research
- Targeted drug panels
- Drug-monitoring research
- Toxicology method development
- Multi-analyte quantitation
Pharma and Bioanalysis
- ADME research
- Pharmacokinetic studies
- Peptide quantitation
- Drug discovery workflows
Food and Environmental Research
- Pesticide analysis
- Contaminant monitoring
- Residue analysis
- Complex-matrix methods
Application suitability and regulatory status depend on the complete configuration, validated method and intended use.
Available System Configurations
Mass Spectrometer Platform
The 6460C may be quoted for connection to an existing compatible LC. Confirm interface requirements, source, workstation, software, vacuum equipment, gases and installation scope.
Configured LC-MS/MS System
A compatible Agilent 1260 or 1290 LC configuration may be available. Module models and included hardware vary by inventory and must be listed individually in the quotation.
Compare Refurbished Agilent LC-MS Systems
| System | Analyzer | Best Fit | Key Distinction |
|---|---|---|---|
| Agilent 6460C | Triple quadrupole | Routine targeted quantitation | m/z 5-3,000 and 30 ms polarity switching |
| Agilent 6490A | Triple quadrupole with iFunnel | Higher-sensitivity targeted quantitation | iFunnel ion optics and 20 ms polarity switching |
| Agilent 6550A | Quadrupole time-of-flight | Accurate-mass identification and non-targeted research | High-resolution accurate-mass MS and MS/MS |
Analyzer selection should be based on method goals, required sensitivity and selectivity, acquisition strategy, existing methods, software, regulatory requirements and serviceability.
LC-MS/MS Workflow Support
Explore Jant resources for LC-MS/MS instrumentation, custom reagents and method support.
Browse LC-MS Products and Services Custom LC-MS/MS Reagents Method Transfer and Validation Request an ROI ProposalImportant Refurbished-System Information
- Confirm instrument serial number, refurbishment scope, test results and cosmetic condition.
- Confirm whether the quote is for the mass spectrometer only or a complete LC-MS/MS configuration.
- Confirm all LC modules, ion source, probes, vacuum pumps, nitrogen generator or gas requirements, workstation, monitor, software versions, licenses, cables and accessories.
- Installation and starter materials are listed separately on the current Jant page unless included in the quotation.
- The current Jant page states a 90-day warranty with a one-year upgrade option; confirm current coverage, exclusions and service availability in writing.
- Confirm whether IQ/OQ, preventive maintenance, training and method services are included or available separately.
- Regulatory status depends on the exact configuration, documentation and intended use. Do not assume that a refurbished research configuration is cleared for diagnostic use.
Documentation and Resources
Review the Agilent 6400 Series guides hosted by Jant and request documentation for the exact refurbished configuration being quoted.
Agilent 6400 Series Concepts Guide Agilent 6400 Series Quick Start GuideFrequently Asked Questions
The 6460C is a triple-quadrupole LC-MS/MS platform designed primarily for targeted quantitative analysis using MRM-based acquisition. Application suitability depends on the method, configuration and intended use.
Both are triple-quadrupole instruments. The 6490A adds iFunnel ion optics and faster 20 ms polarity switching for more demanding sensitivity requirements, while the 6460C provides a broad m/z 5-3,000 mass range and established targeted-quantitation workflow.
The 6550A is a high-resolution accurate-mass Q-TOF system designed for compound identification, profiling and non-targeted or confirmation research. It is not simply a higher-sensitivity replacement for a triple quadrupole; the analyzer and acquisition goals are different.
Not necessarily. The 6460C may be quoted as a mass-spectrometer platform or with a compatible LC configuration. Confirm every LC module and accessory in the quotation.
Software, license version, workstation and computer hardware are configuration-specific. They should be listed explicitly in the Jant quotation.
The current Jant listing states a 90-day warranty and indicates that a one-year upgrade may be available. Confirm the current warranty, covered components, response terms and exclusions before purchase.
Jant offers custom premixed internal standards and quality-control materials, along with method-transfer and validation services for supported workflows. Contact Jant to review the method and analyte requirements.
Confirm the serial number, refurbishment and test documentation, LC configuration, source, probes, pumps, gas requirements, workstation, software and licenses, installation, training, warranty, serviceability, shipping and regulatory designation.
Ordering Information
To request availability, configuration details or a quote, call Jant Pharmacal at 800.676.5565
| Catalog Number | Description | Unit of Measurement |
|---|---|---|
| ALT6460C | Agilent 6460C Triple Quadrupole LC-MS/MS System – Refurbished | Each |
Please confirm the complete configuration, included LC modules and accessories, condition, software, warranty, installation and service coverage when requesting a quote.