Product Overview
The SCIEX Triple Quad™ 4500 LC-MS/MS System is a triple-quadrupole mass spectrometer designed for targeted quantitative analysis using multiple reaction monitoring (MRM). The 4500 Series combines fast scanning and polarity switching with a source flow range suited to standard and UHPLC separations.
Designed for repeated analysis of complex samples, the system supports quantitative workflows across clinical research, toxicology, drug-monitoring research, pharmaceutical and bioanalytical studies, food and environmental testing, and targeted proteomics.
Jant Pharmacal can also support laboratories with custom premixed LC-MS/MS internal standards and quality-control materials, along with LC-MS/MS method transfer and validation services.
The listed product is the SCIEX Triple Quad 4500 under Jant catalog number ABS4500. QTRAP functionality is configuration-specific and should not be assumed to be included.
20,000 Da/s Scan Speed
Fast scanning supports quantitative workflows and short chromatographic peaks.
50 ms Polarity Switching
Positive- and negative-ion compounds can be addressed within a single acquisition workflow.
Dwell Times as Low as 1 ms
Supports monitoring of multiple compounds during fast LC and UHPLC separations.
Key Features
- Triple-quadrupole LC-MS/MS platform for targeted quantitative analysis
- Multiple reaction monitoring and Scheduled MRM acquisition
- Scan speeds up to 20,000 Da/s
- Polarity switching in 50 ms
- Dwell times as low as 1 ms
- Source flow range from 50 µL/min to 3 mL/min, supporting narrow-bore, standard-bore and UHPLC workflows
- TurboIonSpray and APCI probe options, depending on the quoted source configuration
- QJet ion guide and high-pressure collisional focusing for ion transmission
- AcQuRate pulse-counting detector with pulse-overlap correction
- Qurved LINAC high-pressure collision-cell design
- Analyst and SCIEX OS software options, depending on system configuration and licensing
- Optional QTRAP configuration adds linear-ion-trap and enhanced scan functionality
Product Specifications
| Jant Catalog Number | ABS4500 |
|---|---|
| Product | SCIEX Triple Quad™ 4500 LC-MS/MS System |
| Analyzer Type | Triple-quadrupole liquid chromatography tandem mass spectrometer |
| Primary Acquisition | MRM and Scheduled MRM targeted quantitative workflows |
| Scan Speed | Up to 20,000 Da/s |
| Polarity Switching | 50 ms |
| Minimum Dwell Time | As low as 1 ms |
| Ion-Source Flow Range | 50 µL/min to 3 mL/min |
| Ionization Options | TurboIonSpray probe for electrospray ionization and optional APCI probe, depending on configuration |
| Liquid-Chromatography Compatibility | Narrow-bore, standard-bore and UHPLC workflows within the applicable source-flow range |
| Software | Analyst software and SCIEX OS options; exact version, licensing and compatibility depend on system configuration |
| QTRAP Functionality | Available only with a QTRAP-enabled configuration; not assumed to be included with the listed Triple Quad 4500 |
| Unit of Measurement | Each |
LC-MS/MS Applications
Clinical Research and Toxicology
- Drug-monitoring research
- Clinical toxicology workflows
- Drugs-of-abuse applications
- Targeted quantitative panels
Pharma and Bioanalysis
- ADME research
- Regulated bioanalysis
- Drug discovery and development
- Peptide quantification
Food and Environmental Testing
- Contaminant screening
- Pesticide analysis
- Multi-component quantitative methods
- Complex-matrix analysis
Application suitability and regulatory status depend on the instrument configuration, software, validated method and intended use.
Triple Quad 4500 and QTRAP 4500 Configurations
SCIEX Triple Quad 4500
Designed for targeted LC-MS/MS quantitation using triple-quadrupole acquisition modes such as MRM and Scheduled MRM.
Jant catalog ABS4500 is listed as the Triple Quad 4500.
QTRAP 4500
A QTRAP-enabled configuration adds linear-ion-trap functionality and enhanced scan modes, including enhanced product ion acquisition and MS3 workflows.
Confirm QTRAP configuration and licensing separately when requesting a quote.
LC-MS/MS Reagents and Workflow Support
Connect the SCIEX Triple Quad 4500 with Jant Pharmacal’s LC-MS/MS reagent and laboratory-support resources. Jant can work with laboratories on custom premixed internal standards and quality-control materials, method transfer and validation, and financial-feasibility planning.
Explore Custom LC-MS/MS Reagents View Method Transfer and Validation Browse LC-MS Products and Services Request an ROI ProposalImportant Product Information
- Jant catalog ABS4500 is listed as the SCIEX Triple Quad 4500.
- The linked brochure describes the QTRAP 4500 system. Linear-ion-trap and QTRAP scan functionality should not be assumed to be included with the listed Triple Quad configuration.
- Confirm whether the quoted system is a research-use or IVD/medical-device configuration and whether it is authorized for the laboratory’s intended use.
- Confirm instrument condition, included LC system, source, probes, vacuum equipment, gas requirements, workstation, software versions, licenses, installation, training, warranty and service coverage before purchase.
- Applications require laboratory verification or validation according to the intended use and applicable requirements.
- Specifications, configurations and availability may change; verify the current quotation and manufacturer documentation.
Documentation and Resources
Review the available system literature and contact Jant Pharmacal for the documentation applicable to the exact system configuration being quoted.
SCIEX QTRAP 4500 System Brochure Custom LC-MS/MS Internal Standards and Controls LC-MS/MS Method Transfer and ValidationFrequently Asked Questions
The SCIEX Triple Quad 4500 is a triple-quadrupole LC-MS/MS system designed for targeted quantitative analysis using acquisition modes such as MRM and Scheduled MRM.
The 4500 Series supports scan speeds up to 20,000 Da/s and polarity switching in 50 ms. Dwell times can be as low as 1 ms.
Yes. The system is designed to support fast LC and UHPLC workflows. The referenced source configuration supports flow rates from 50 µL/min to 3 mL/min. Confirm compatibility with the exact LC and source configuration being quoted.
The Triple Quad 4500 is designed primarily for targeted triple-quadrupole quantitation. A QTRAP 4500 configuration adds linear-ion-trap functionality and enhanced scan modes for additional qualitative and confirmation workflows.
The current Jant listing identifies ABS4500 as the SCIEX Triple Quad 4500. QTRAP functionality should not be assumed to be included. Contact Jant Pharmacal to confirm the exact instrument configuration.
Application areas may include clinical and toxicology research, drug-monitoring research, pharmaceutical bioanalysis, ADME studies, food and environmental contaminant analysis, and targeted quantitative proteomics. Suitability depends on the validated method and regulatory status of the system.
Yes. Jant offers custom premixed LC-MS/MS internal standards and quality-control materials developed around laboratory-supplied specifications such as analytes, concentrations, solvent or matrix, fill volume, packaging and delivery needs.
Yes. Review Jant’s LC-MS/MS Method Transfer and Validation resource for available analytes and inquiry information.
Regulatory status depends on the specific system configuration and market. SCIEX distinguishes its IVD medical-device portfolio from its research-use products. Confirm the regulatory designation of the exact quoted system and ensure that the intended application is appropriately verified or validated.
Confirm the instrument configuration and condition, included LC system, source and probes, vacuum and gas equipment, workstation, software and licenses, installation, training, warranty, service coverage, shipping requirements and regulatory designation.
Ordering Information
To request availability, system configuration or a quote, call Jant Pharmacal at 800.676.5565
| Catalog Number | Description | Unit of Measurement |
|---|---|---|
| ABS4500 | SCIEX Triple Quad™ 4500 Liquid Chromatograph Tandem Mass Spectrometer | Each |
Please confirm the complete system configuration, included components, condition, software, service coverage and regulatory designation when requesting a quote.