VIASURE Monkeypox RT PCR Kit is a real-time PCR test designed for the qualitative identification of DNA from Monkeypox virus in clinical samples from individuals suspected of Monkeypox virus infection by their healthcare professional (HCP). This test is intended to be used for research purposes, without any medical objective is not regarded as devices for performance evaluation. DNA is extracted from clinical specimens, amplified using real-time PCR and detected using fluorescent reporter dye probes specific for Monkeypox virus.
Monkeypox virus (MPXV) is an enveloped double‐stranded DNA virus. It belongs to the Orthopoxvirus genus of the Poxviridae family. The Orthopoxvirus genus also includes Vaccinia virus, Cowpox virus, Variola virus and several other, animal-related, poxviruses. Two phylogenetically distinct clades of MPXV have been identified through genomic sequencing: the Central African (Congo Basin) clade and the West African clade. Typically, the Central African MPXV is associated with more severe disease, higher mortality, and more frequent human-to-human transmission.
MPXV is transmitted to humans through contact with an infected animal or human, or with material contaminated with the virus. The virus enters the body through broken skin, the respiratory tract or the mucous membranes. The incubation period of monkeypox is usually from 6 to 13 days but can range from 5 to 21 days. Virus transmission through direct or indirect contact with live or dead animals is assumed to be the main factor for human MPX infections. This may occur by bite or scratch, bush meat preparation, direct contact with body fluids or lesions from an infected animal or contaminated material (indirect contact). Eating inadequately cooked meat of an infected animal is an additional possible risk factor. Similar to smallpox, human-to-human transmission of MPXV occurs mostly through large respiratory droplets during direct and prolonged face-to-face contact. In addition, MPXV can be transmitted by direct contact with body fluids of an infected person or with contaminated objects, such as bedding or clothing.
Human monkeypox often begins with a combination of the following symptoms: fever, headache, chills, exhaustion, asthenia, lymph node swelling, back pain and muscle aches. Commonly, within one to three days after onset of fever, the patient develops a rash, which tends to first appear on the face and then spreads to other parts of the body, including hands and feet. The cutaneous lesions often first present as macules, evolving successively to papules, vesicles, pustules, crusts and scabs. The main difference between smallpox and MPX is that MPXV causes lymphadenopathy (e.g. in the cervical or inguinal region) while smallpox virus and chickenpox virus usually do not. The study of Immune markers has provided evidence of asymptomatic MPX infections in individuals vaccinated against smallpox and others that had not been vaccinated. For most people, MPX is a self-limited disease, typically lasting two to four weeks and resulting in complete recovery.
The Monkeypox RT PCR Kit is available in strip or tube format.
More information about monkeypox from the CDC:
2022 U.S. Map & Case Count (see below)
2022 Monkeypox Outbreak Global Map (click to view on CDC website)
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|JTVSMPX196TRUO||VIASURE Monkeypox virus Real Time PCR Detection Reagents RUO||4 tubes x 24 rxn|
|JTVSMPX106LRUO||VIASURE Monkeypox virus Real Time PCR Detection Reagents RUO||6 x 8-well strips, low profile|
|JTVSMPX106HRUO||VIASURE Monkeypox virus Real Time PCR Detection Reagents RUO||6 x 8-well strips, high profile|
|JTVSMPX112LRUO||VIASURE Monkeypox virus Real Time PCR Detection Reagents RUO||12 x 8-well strips, low profile|
|JTVSMPX112HRUO||VIASURE Monkeypox virus Real Time PCR Detection Reagents RUO||12 x 8-well strips, high profile|