Product Overview
The Tosoh HLC-723G8 HPLC Analyzer is a fully automated benchtop system for the quantitative measurement of hemoglobin A1c (HbA1c) in venous whole blood. The analyzer uses nonporous ion-exchange high-performance liquid chromatography (HPLC) to separate hemoglobin fractions and reports HbA1c as both % HbA1c (DCCT/NGSP) and mmol/mol HbA1c (IFCC).
In Variant Mode, the G8 completes HbA1c analysis in 1.6 minutes per sample. Direct primary-tube sampling, cap piercing, automatic startup, automated daily maintenance and a compact footprint help streamline routine HbA1c testing in clinical laboratories.
Jant catalog number TOS0021560-90SL identifies the G8 analyzer with the 90-sample loader configuration. The 90SL accommodates nine 10-position racks plus one dedicated STAT sample position. Contact Jant Pharmacal to confirm current availability, included components, installation requirements and support options.
1.6-Minute Variant Analysis
Rapid HbA1c analysis using ion-exchange HPLC, with the first result available in approximately 3.5 minutes.
90 Samples Plus STAT
The Jant-listed 90SL configuration holds nine 10-position racks and includes one dedicated STAT position.
Precision and Chromatograms
Published product specifications report precision of less than 2% CV, with a numerical result and chromatogram produced for each sample.
Key Features
- Fully automated ion-exchange HPLC analysis for quantitative HbA1c measurement
- Variant Mode analysis time of 1.6 minutes per sample
- Direct sampling from primary EDTA whole-blood tubes with cap-piercing capability
- No offline sample pretreatment required for routine whole-blood testing
- 90-sample loader with nine 10-position racks and one dedicated STAT position
- Continuous loading of sample racks during operation
- Primary and secondary sample tubes can be accommodated in the same rack when used in accordance with the operator instructions
- Touch-panel interface and automatic startup
- Automated daily maintenance functions
- Onboard storage for up to 800 sample records
- Bidirectional RS-232C host communication
- Compact benchtop footprint for the 90SL configuration
Automated HbA1c Workflow
1. Load Samples
Load K2-EDTA or K3-EDTA venous whole-blood specimens in compatible primary or secondary tubes. The 90SL holds up to 90 routine samples plus one STAT sample.
2. Separate by HPLC
The analyzer prepares the sample and uses a dedicated cation-exchange column with three elution buffers to separate hemoglobin fractions.
3. Review the Result
Visible two-wavelength absorbance detection generates an HbA1c result and chromatogram. Review all instrument flags and chromatograms according to the current labeling.
Product Specifications
| Jant Catalog Number | TOS0021560-90SL |
|---|---|
| Manufacturer Model | Tosoh Automated Glycohemoglobin Analyzer HLC-723G8 with 90SL loader |
| Intended Use | Quantitative measurement of % HbA1c (DCCT/NGSP) and mmol/mol HbA1c (IFCC) in venous whole blood |
| Regulatory Status | FDA-cleared Class II prescription in vitro diagnostic device; 510(k) K131580 |
| Analytical Principle | Nonporous ion-exchange high-performance liquid chromatography (HPLC) |
| Operating Mode Featured | Variant Mode |
| Variant Mode Analysis Time | 1.6 minutes per sample |
| Time to First Result | Approximately 3.5 minutes |
| Specimen | Venous whole blood collected in K2-EDTA or K3-EDTA; whole-blood and pre-diluted sample workflows are supported |
| Assay Range | 4.0–16.9% HbA1c |
| Sample Loader Capacity | 90 samples in nine 10-position racks |
| STAT Capacity | One dedicated STAT position |
| Compatible Tube Size | 12–15 mm diameter × 75–100 mm height |
| Detection | Visible, two-wavelength absorption photometry |
| Stored Results | Up to 800 sample records |
| Host Communication | Bidirectional RS-232C |
| Operating Temperature | 15–30°C (59–86°F) |
| Power Requirements | 100–240 V AC, 50/60 Hz, 180 VA |
| 90SL Dimensions | 530 mm W × 515 mm D × 482 mm H (approximately 21 × 20 × 19 inches) |
| 90SL Weight | Approximately 34 kg (75 lb) |
| Unit of Measurement | Each |
Specifications are based on the Jant-hosted Tosoh brochure, current Tosoh U.S. product information and FDA 510(k) K131580. Current U.S. labeling, the quoted configuration and manufacturer documentation control. Confirm site requirements and included components before purchase.
Compare G8 Loader Configurations
The G8 platform has been offered with 90-sample and 290-sample loaders. Jant catalog number TOS0021560-90SL is the 90-sample configuration shown on this page.
| Feature | G8-90SL | G8-290SL |
|---|---|---|
| Routine Sample Capacity | 90 samples | 290 samples |
| Rack Capacity | Nine 10-position racks | Twenty-nine 10-position racks |
| STAT Position | One | One |
| Dimensions | 530 × 515 × 482 mm (21 × 20 × 19 in) |
1120 × 530 × 482 mm (44 × 21 × 19 in) |
| Weight | Approximately 34 kg (75 lb) | Approximately 51.5 kg (114 lb) |
| Jant Listing | TOS0021560-90SL | Contact Jant to discuss availability |
Tosoh G8 Reagents, Calibrators and Controls
The G8 Variant workflow uses designated Tosoh system products. Contact Jant Pharmacal to confirm current U.S. item numbers, packaging, regulatory status and availability for your analyzer and software configuration.
Separation and Wash Components
- TSKgel G8 Variant HSi Column
- G8 Variant Elution Buffer HSi No. 1
- G8 Variant Elution Buffer HSi No. 2
- G8 Variant Elution Buffer HSi No. 3
- HSi Hemolysis & Wash Solution
Calibration and Quality Control
- Tosoh HbA1c calibrator materials specified for the G8 method
- HbA1c quality-control materials suitable for the laboratory’s G8 procedure
- System consumables and maintenance supplies specified in the current operator documentation
The G8 is not presented here as an open-channel analyzer. Tosoh documentation specifies designated G8 columns and reagents. Links to broader Jant categories are provided as laboratory resources and do not indicate compatibility with the G8. Verify every reagent, calibrator, control and consumable against current Tosoh U.S. labeling before use.
Important Product Information
- The HLC-723G8 is an FDA-cleared prescription in vitro diagnostic device for professional laboratory use.
- HbA1c results should be interpreted with the patient’s clinical presentation and other laboratory findings; they should not be the sole basis for a diagnosis.
- Review every chromatogram, instrument flag and nonstandard peak according to the current Tosoh instructions.
- The FDA 510(k) summary identifies HbE as an interference. When HbE is suspected, the instrument flags the sample and does not report an HbA1c result.
- Hemoglobin variants, elevated HbF, sample condition and other factors may affect individual specimens or interpretation. Follow the current limitations and interference information.
- The analyzer requires designated Tosoh G8 columns, elution buffers, wash solution and other specified system products.
- NGSP certification is time-limited and renewed periodically. Verify the current certification status directly with NGSP or Tosoh when certification is a purchasing or accreditation requirement.
- Current U.S. labeling and the specific quoted configuration take precedence over summary information on this page.
Documentation and Resources
Review the product literature and FDA clearance summary for intended use, specifications, performance information, limitations and system requirements.
Product Documentation
Tosoh G8 Product Brochure FDA 510(k) K131580 SummaryClinical and Technical Resources
The following resources provide additional technical and clinical context. They do not replace the current U.S. product labeling, operator instructions or laboratory procedures.
Hemoglobin Variant Study — G8 v5.24F Clinical Article: Elevated HbF in HbA1c TestingThe scientific poster evaluates G8 software version 5.24F with selected hemoglobin variants and elevated HbF. The MLO article is an educational resource about elevated fetal hemoglobin in HbA1c testing. Review each publication for its methods, scope and limitations.
Frequently Asked Questions
The Tosoh HLC-723G8 is a fully automated benchtop ion-exchange HPLC analyzer for the quantitative measurement of HbA1c in venous whole blood. It produces a numerical result and a chromatogram for each sample.
The FDA-cleared intended use is the quantitative measurement of % HbA1c (DCCT/NGSP) and mmol/mol HbA1c (IFCC) in venous whole blood. The measurement is used as an aid in the diagnosis of diabetes and in identifying patients who may be at risk for developing diabetes. Follow the complete current U.S. labeling.
Variant Mode analysis takes 1.6 minutes per sample. The product brochure lists approximately 3.5 minutes to the first result.
Current U.S. product information specifies venous whole blood collected in K2-EDTA or K3-EDTA. Whole-blood and pre-diluted workflows are supported when performed according to the current operator instructions.
The G8-90SL holds nine 10-position racks for up to 90 routine specimens and includes one dedicated STAT sample position. Racks can be loaded continuously during operation.
No offline pretreatment is required for the routine primary-tube whole-blood workflow. The analyzer performs the required sample preparation as part of the automated process.
Current U.S. product information lists an assay range of 4.0–16.9% HbA1c for the G8. Follow current labeling for reporting, repeat testing and results outside the measuring range.
Variants, elevated HbF and nonstandard peaks require review of the chromatogram and instrument flags. The FDA 510(k) summary specifically identifies HbE as an interference; when HbE is suspected, the instrument flags the sample and does not report an HbA1c result. A separate scientific poster evaluates software version 5.24F with selected variants and elevated HbF, but the current U.S. labeling and the laboratory’s validated procedures should determine how results are reviewed and reported.
The Variant workflow uses the designated TSKgel G8 Variant HSi Column, three G8 Variant Elution Buffer HSi solutions, HSi Hemolysis & Wash Solution, and the applicable calibrators, controls and system consumables. Contact Jant to confirm current U.S. item numbers and availability.
The G8 reports % HbA1c in DCCT/NGSP units and mmol/mol in IFCC units. NGSP certification is renewed periodically and has an expiration date, so laboratories should verify the current certificate directly with NGSP or Tosoh rather than relying on an undated webpage statement.
Yes. Jant Pharmacal can help review the loader configuration, laboratory volume, required consumables, installation considerations and support needs. You can also request a complimentary ROI proposal.
Ordering Information
To request current availability, system configuration or a quote, call Jant Pharmacal at 800.676.5565
| Catalog Number | Description | Unit of Measurement |
|---|---|---|
| TOS0021560-90SL | Tosoh HLC-723G8 HbA1c Analyzer with 90-Sample Loader | Each |
Confirm current availability, included loader and accessories, reagent package, installation, training, warranty and service coverage when requesting a quote.